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应用免疫组织化学抗生蛋白链菌素———生物素标记法（ＬＳＡＢ法），对１２２例乳腺癌ｎｍ２３基因的表达及其与淋巴结转移的关系进行了研究。结果显示：１２２例乳腺癌ｎｍ２３基因阳性率为５１．６％（６３／１２２），而有腋窝淋巴结转移的５３例乳腺癌，其阳性率为２８．３％（１５／５３），无腋窝淋巴结转移的６９例，阳性率为６９．６％（４８／６９），两者有非常显著差异（Ｐ＜０．０１）。同时发现ｎｍ２３基因表达与乳腺癌组织学分类、肿瘤大小、年龄无相关性。提示ｎｍ２３基因不仅在乳腺癌中具有高表达，而且在乳腺癌淋巴结转移中起重要作用。因此，检测ｎｍ２３基因表达可作为临床预测乳腺癌淋巴结转移趋势的重要参考指标之一，对判断预后和制定治疗方案具有参考价值。
Immunohistochemical streptavidin--biotin labeling method (LSAB method) was used to study the expression of nm23 in breast cancer and its relationship with lymph node metastasis. The results showed that the positive rate of nm23 in 51 cases of breast cancer was 51.6% (63/122), and in 53 cases of breast cancer with axillary lymph node metastases, the positive rate was 28.3% (15/53). There was no axillary lymph node 69 cases of metastasis, the positive rate was 69.6% (48/69), there is a very significant difference between the two (P <0.01). At the same time, it was found that there was no correlation between nm23 gene expression and the histological classification, tumor size, and age of breast cancer. It is suggested that nm23 gene not only has high expression in breast cancer, but also plays an important role in lymph node metastasis of breast cancer. Therefore, the detection of nm23 gene expression can be used as one of the important reference indexes for predicting the lymph node metastasis in breast cancer clinically, which is of reference value for judging the prognosis and formulating the treatment plan.