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78例慢乙肝患者尿β_2微球蛋白(β_2MG),尿白蛋白(ALB)及IgG明显高于正常组,慢活肝组亦显著高于慢迁肝组。血β_2MG各组间相近。慢活肝患者尿IgG增高显著,与尿ALB呈高度正相关(r=0.95,P<0.01),16例慢活肝活动期尿β_2MG、ALB及IgG略高于恢复期。提示慢乙肝患者可合并肾脏病变,其严重程度符合免疫损伤规律。并认为慢活肝患者的肾功能受损可能是一种不可逆状态。而尿β_2MG、ALB及IgG的检测可较早发现其肾脏损害。
78 cases of chronic hepatitis B patients with urinary β 2 microglobulin (β 2 MG), urinary albumin (ALB) and IgG were significantly higher than the normal group, the slow-living liver group was also significantly higher than the slow-moving liver group. Blood β_2MG similar between the various groups. Urine IgG was significantly increased in patients with chronic liver disease and was positively correlated with urine ALB (r = 0.95, P <0.01). Urinary IgG, ALB and IgG in 16 patients with chronic liver activity were slightly higher than those in patients with recovery. Prompt patients with chronic hepatitis B may be associated with renal disease, the severity consistent with the law of immune injury. And that chronic renal failure in patients with impaired liver function may be an irreversible state. The urinary β_2MG, ALB and IgG detection can be found earlier in the kidney damage.