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骨髓间充质干细胞(Bone marrow mesenchymal stemcells,BMSCs)是目前国际上非常关注的一类存在于骨髓中的非造血干细胞,其具有多向分化的潜能,在适宜的条件下能分化为成骨、软骨、脂肪、肌腱、肌肉、神经元细胞等。近年来研究发现,BMSCs除具有多向分化潜能及支持体外造血、促进体内造血功能重建外,对T细胞增殖有明显抑制作用,随后又发现其对B细胞、树突状细胞和自然杀伤细胞都有类似作用,表明BMSCs可能具有治疗免疫性疾病和移植排斥反应的前
Bone marrow mesenchymal stem cells (BMSCs) are a kind of non-hematopoietic stem cells in bone marrow that are currently very much concerned in the world. They have the potential of multidirectional differentiation and can differentiate into osteogenic, Cartilage, fat, tendon, muscle, neuronal cells and the like. In recent years, studies have found that, in addition to having a multi-directional differentiation potential of BMSCs and support for hematopoiesis in vitro, and promote the reconstruction of hematopoietic function in vivo, BMSCs significantly inhibit the proliferation of T cells, and subsequently found that B cells, dendritic cells and natural killer cells Had similar effects, suggesting that BMSCs may have the potential to treat immunological diseases and transplant rejection before