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目的:观察小针刀治疗颈源性头痛的疗效,探讨其可能机制。方法:67例颈源性头痛患者随机分为观察组(n=35,采用小针刀加内科药物治疗)、对照组(n=32,采用药物加针灸治疗)。采用放射免疫分析法测定血清细胞因子肿瘤坏死因子-α(TNF-α),白介素6(IL-6)含量,观察两组治疗前后血清细胞因子TNF-α、IL-6活性水平。结果:观察组显效率为80.0%(28/35),对照组为68.8%(22/32),观察组疗效明显比药物组好(P<0.05);治疗前,观察组和药物组的血清TNF-α,IL-6活性水平相比差异无统计学意义(P>0.05),两组治疗4周后,观察组血清TNF-αI、L-6活性水平明显比药物组低(P<0.05,P<0.01)。结论:通过抑制TNF-αI、L-6介导的炎性反应,缓解头痛症状,可能是针刀治疗颈源性头痛机制之一。
Objective: To observe the curative effect of small needle knife on cervical headache and to explore its possible mechanism. Methods: Sixty-seven patients with cervical headache were randomly divided into observation group (n = 35, treated with small needle knife and internal medicine) and control group (n = 32, treated with medicine plus acupuncture). Serum levels of TNF-α and IL-6 were measured by radioimmunoassay. The levels of serum cytokines TNF-α and IL-6 before and after treatment were observed. Results: The markedly effective rate was 80.0% (28/35) in the observation group and 68.8% (22/32) in the control group, and the effect of the observation group was significantly better than that of the drug group (P <0.05). Before treatment, the serum of the observation group and the drug group The levels of TNF-α and IL-6 in the two groups after treatment for 4 weeks were significantly lower than those in the drug group (P <0.05) , P <0.01). Conclusion: The mechanism of acupuncture treatment of cervical headache may be one of the mechanisms of acupuncture treatment of headache by inhibiting the inflammatory reaction induced by TNF-αI and L-6 and relieving the symptoms of headache.