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通过孕期强化免疫观察母血特异性抗体水平。将门诊孕28-34周孕妇48例分成研究组和对照组。研究组含服脊髓灰质炎活疫苗,临产前分别抽取两组孕妇肘静脉血,用ELIAS检测IgG抗体水平。结果:研究组母血抗脊髓灰质炎IgG抗体水平明显高于对照组;两组脊灰病毒Ⅰ、Ⅱ、Ⅲ型抗原所产生的IgG抗体效价1:200有显著差异(P<0.01)。提示孕期强化免疫能增加母血中特异性抗体水平,但为安全起见,也为避免孕期免疫抑制的干扰,强化免疫应在婚龄期或孕前期进行。
Maternal blood specific antibody levels were observed by fortified immunization during pregnancy. The outpatient pregnant 28-34 weeks pregnant women 48 cases were divided into study group and control group. The study group was given live poliomyelitis vaccine, and two groups of elbow venous blood of pregnant women were taken before labor, and the level of IgG antibody was detected by ELIAS. Results: The level of maternal serum anti-polio IgG in the study group was significantly higher than that in the control group. The titer of IgG antibody produced by the two groups of poliovirus types Ⅰ, Ⅱ and Ⅲ was significantly different (P <0.01). Prompted that during pregnancy enhanced immunity can increase the level of specific antibodies in maternal blood, but for safety reasons, but also to avoid the interference of immunosuppression during pregnancy, intensive immunization should be carried out in the marriage age or pre-pregnancy.