论文部分内容阅读
本文旨在研究晚期肾脏病(ESRD)需血透维持患者的血浆儿茶酚胺的水平以评价透析对其可能的作用。病人与方法:(1)自愿受试患者11例,5例男性,6例女性,年龄30—85岁(平均56.5±20.4SD);11例中糖尿病肾病5例,慢性肾小球肾炎3例,高血压性肾小动脉硬化性肾硬化3例(其中1例已行左肾切除术)。透析前收缩压和舒张压(平均±SD)分别为151±18及73±14mmHg,全部病人未服任何抗高血压或其它已知干扰血浆儿茶酚胺测定的药物。(2)每例病人每周透析三次,每次透析4小时。(3)在透析中根据体重之增加使用超滤以除去水份,并在每次透析结束时测定和记录体重。(3)全部病人半卧位休息30分钟后抽血测定去甲肾上腺素、(NE)肾上腺素(E)及多巴胺(DA)。随后受试者以同一体位,在透析临近结束前抽取动脉端与静脉
This article aims to investigate the need for hemodialysis in patients with advanced renal disease (ESRD) to maintain plasma catecholamine levels in patients in order to evaluate the possible role of dialysis. Patients and Methods: (1) 11 volunteers, 5 males and 6 females, aged 30-85 years (average 56.5 ± 20.4SD); 11 diabetic nephropathy in 5 cases, 3 chronic glomerulonephritis , 3 cases of hypertensive renal arteriosclerotic nephrosclerosis (including 1 case left nephrectomy). Pre-dialysis systolic and diastolic blood pressure (mean ± SD) were 151 ± 18 and 73 ± 14 mmHg, respectively, and all patients were given no antihypertensive or other medications known to interfere with plasma catecholamines. (2) Each patient dialysis three times a week, each dialysis for 4 hours. (3) Use ultrafiltration to remove moisture during dialysis, based on weight gain, and measure and record body weight at the end of each dialysis. (3) All patients were tested for norepinephrine (NE), epinephrine (E) and dopamine (DA) 30 minutes after resting in the semi-supine position. The subjects then took the same position, drawing the arterial tip and vein just before the end of dialysis