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慢性肾功能不全时,由于维生素D在肾脏的活性降低,常引起血清钙降低和血清磷上升。但在肾后性慢性肾功能不全的病例中,血清钙和磷的变化却很轻微,维生素D的活性并不减低。为此有人曾以大鼠作实验,分别用摘除动物的两侧肾脏或结扎输尿管的方法以造成尿毒症,结果发现两种情况对维生素D代谢过程的影响不同。作者将临床诊断为尿毒症者分为肾实质本身破坏的肾性尿毒症及尿路通过障碍造成肾机能减低的肾后性尿毒症两组,对两组病人的血清钙、磷值进行了测定,并加以讨论。肾性尿毒症11例,包括慢性肾小球炎、多囊肾、肾硬化症、肾结核。肾后性尿毒症9例,包括前列腺肥大、前列腺癌、妇科的泌尿道疾病等。发现两组尿毒症患者之血清钙,磷的值与血清肌酸酐及尿素氮含量的变化都没有明显的相关。但是在肾性尿毒症组,血清钙的平均值为6.74±1,19毫克％(P=0.05),比正常有明显的减低,其中血清钙在7.0毫克％以下
Chronic renal insufficiency, due to decreased activity of vitamin D in the kidneys, often lead to decreased serum calcium and serum phosphorus. However, in patients with chronic renal failure after renal calcium and phosphorus changes in serum is very slight, vitamin D activity is not reduced. For this reason, some people have experiments with rats, respectively, by removing both sides of the kidneys or ligation of the ureter urethra caused by uremia and found that the two cases of vitamin D metabolic processes are different. The author will be clinically diagnosed as uremia were divided into renal parenchymal destruction of renal uremia and renal failure caused by urinary tract dysfunction in the two groups of renal uremia, the two groups of patients serum calcium and phosphorus were measured , And discuss it. Renal uremia in 11 cases, including chronic glomerular inflammation, polycystic kidney disease, renal sclerosis, renal tuberculosis. Renal uremia in 9 cases, including benign prostatic hyperplasia, prostate cancer, gynecological urinary tract diseases. Found that two groups of uremia patients serum calcium and phosphorus values and serum creatinine and urea nitrogen content changes are not significantly correlated. However, in the group of renal uremia, the mean value of serum calcium was 6.74 ± 1 and 19 mg% (P = 0.05), which was significantly lower than that of the normal group, of which serum calcium was below 7.0 mg%