尿素水溶液极不安定,灭菌后分解出游离氨,致使pH明显升高,而不适于静脉注射使用。目前各医院已将用尿素重结晶法来制备固体剂型,但在具体制备中仍存在着一些问题,我们针对这些问题,进行了初步的研究。 Urea water solution is very unstable, decomposed free ammonia after sterilization, resulting in a significant increase in pH, but not suitable for intravenous use. At present, the hospitals have already prepared the solid dosage form by the urea recrystallization method, but there are still some problems in the specific preparation. We have conducted a preliminary study on these problems.