本文旨在评价强效口服降压药米诺地尔(Minoxi-dil,简称MD)在第三阶梯治疗时每日一次的效果及其对血浆脂质的影响。作者对11例受试者逐渐撤除原用药,改用氯噻酮50 mg 和纳多洛尔(Nadolol)160 mg,均为每天早晨给药一次,每周随访一次,至少3周。如患者卧位舒张压仍>90 mmHg,上述方案中每日加用一次MD 2.5 mg,并以2.5～5.0 mg 剂量逐步递增, This article aims to evaluate the effect of a once-daily, third-order treatment of Minoxi-dil (MD), a potent oral antihypertensive drug, and its effect on plasma lipids. The authors gradually abolished the original medication in 11 subjects and switched to chlorthalidone 50 mg and nadolol 160 mg. Each morning, they were given once a week for at least 3 weeks. If the patient’s supine diastolic blood pressure is still> 90 mmHg, MD 2.5 mg added once daily in the above-mentioned regimen and gradually increased with a dose of 2.5-5.0 mg,