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通过检测脾细胞增殖反应以及白介素1(IL-1)和白介素2(IL_2)活性,研究了绞股蓝总皂甙(GP)体外对免疫细胞功能的影响。结果表明,GP(2~50mg/L)可明显促进刀豆蛋白A诱导小鼠T淋巴细胞增殖反应和脂多糖诱导B淋巴细胞增殖反应;GP还可促进大鼠腹腔巨噬细胞产生IL_1活性以及脾细胞产生IL_2活性。这些结果提示,GP具有免疫增强作用
By examining the proliferation of spleen cells and the activity of interleukin-1 (IL-1) and interleukin-2 (IL-2), the effects of gypenosides (GP) on the function of immune cells in vitro were studied. The results showed that GP (2-50 mg/L) could significantly promote the proliferation of mouse T lymphocytes induced by concanavalin A and the proliferative response of B lymphocytes induced by lipopolysaccharide; GP also promoted the production of IL 1 in rat peritoneal macrophages. Spleen cells produce IL-2 activity. These results suggest that GP has an immunopotentiating effect