氮α位碳—碳键的形成是合成诸多含氮化合物的关键步骤.厦门大学化学化工学院黄培强课题组的郑啸副教授报道了仲酰胺与脂肪醛(酮)在三甲基氯硅烷作用下生成氯代酰胺;进而在一氯二茂钛催化下与亲电烯烃发生自由基偶联反应,经“一瓶”反应制备了一系列N-取代-γ-氨基酸(酮)衍生物.该反应可一次性串联形成一个碳—氮键和一 The formation of nitrogen α carbon-carbon bond is a key step in the synthesis of many nitrogen-containing compounds.Zheng Xiao, an associate professor of Chemistry and Chemical Engineering at Xiamen University, reported that secondary amides and aliphatic aldehydes (ketones) are generated under the action of trimethylchlorosilane Chlorinated amide; then in the presence of chlorotolyl titanate and electrophilic olefin radical coupling reaction, the “one bottle” reaction prepared a series of N-substituted-γ-amino acid (ketone) derivatives. The reactions can form a single carbon-nitrogen bond and one at a time in series