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目的：了解性激素与子宫肌瘤发病的关系。方法：收集１９９６年３月至１９９６年１２月在我科住院手术治疗的子宫肌瘤患者６７例，其中增生期３１例，分泌期３６例，另设健康妇妇对照７２例，增生期３６例，分泌期３６例。采用放射免疫法测定外周血Ｅ２（雌二醇）、Ｐ（孕酮）、Ｔ（睾酮）、ＦＳＨ（卵泡剌激素）和ＬＨ（黄体生成素）的含量。结果：⑴血清中Ｅ２、Ｐ、ＦＳＨ和ＬＨ含量均随月经周期而变化，Ｅ２和Ｐ变化有显著化差异，Ｔ无周期性变化。⑵研究组激素水平在各个时期均与对照组无明显差异（Ｐ＞０．０５）。结论：子宫肌瘤的发病与外周血Ｅ２、Ｐ、Ｔ、ＦＳＨ的含量关系不大，可能与局部雌、孕激素及其受体含量有关。
Objective: To understand the relationship between sex hormones and uterine fibroids. Methods: From March 1996 to December 1996, 67 cases of uterine fibroids were surgically treated in our department, including 31 cases of proliferative phase, 36 cases of secretory phase, 72 cases of healthy women and 36 cases of proliferative phase , Secretory period in 36 cases. The levels of E2 (estradiol), P (progesterone), T (testosterone), FSH (follicle stimulating hormone) and LH (luteinizing hormone) were measured by radioimmunoassay. Results: (1) The contents of E2, P, FSH and LH in serum all changed with the period of menstruation, the changes of E2 and P were significantly different, and T had no periodic changes. (2) There was no significant difference between study group and control group in hormone levels at all time points (P> 0.05). Conclusion: The incidence of uterine fibroids has little to do with the contents of E2, P, T and FSH in peripheral blood, which may be related to the content of estrogen, progesterone and their receptors.