肥厚型心肌病(hypertrophic cardiomyopathy,HCM)是最常见的遗传性心肌病,也是青年人猝死最常见的原因~([1])。在人群中发病率约为1∶500,50%~60%的患者按照家族性常染色体显性遗传模式遗传,家庭成员中的后代有50%的概率遗传此病~([2])。致病基因主要为心脏肌小节连接蛋白~([3])。HCM临床表现多样,主要与收缩/舒张功能不全、左心室流 Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiomyopathy and is the most common cause of sudden death in young people (1). The incidence in the population is about 1: 500, and 50% to 60% of patients are inherited according to the familial autosomal dominant pattern. Offspring of family members have a 50% probability of inheriting this disease. [2] Pathogenic genes are mainly cardiac myeloid connexin ~ ([3]). HCM clinical manifestations of various, mainly with systolic / diastolic dysfunction, left ventricular flow