目的 :观察小剂量咪唑安定和异丙酚在高血压病患者胃镜检查中的效果和安全性。方法 :胃镜检查的高血压病患者 10 0例随机分为镇静组、对照组。镇静组先行咽喉部局麻 ,再予咪唑安定、异丙酚静注 ;对照组仅行咽喉部局麻 ,观察两组患者对检查感受的不适程度 ,检查中反应情况及检查前、中、后血压 ,心率和血氧饱和度的变化 ,镇静组患者清醒时间。结果 :镇静组对检查感受的不适程度明显低于对照组 (P <0 .0 1)检查中流涎、恶心呕吐、躁动的发生率 (分别为 4%、2 %与 2 % )明显低于对照组 (分别为 42 %、2 4%与 2 8% ,P <0 .0 1) ,镇静组检查中收缩压、舒张压分别较检查前下降 2 2 %、2 0 % ,镇静组患者清醒时间为 ( 1.6± 1.4)min ;对照组检查中收缩压、舒张压分别较检查前升高 19%、17% ,心率增加 19% (P <0 .0 1)。两组检查前与检查后血压、心率、血氧饱和度均无统计学差异。结论 :高血压病患者胃镜检查中应用小剂量咪唑安定和异丙酚静注后能使整个检查过程无痛苦反应 ,且安全性好 Objective: To observe the effect and safety of low dose midazolam and propofol in gastroscopy in patients with essential hypertension. Methods: 100 cases of hypertensive patients underwent gastroscopy were randomly divided into sedation group and control group. Sedation group first throat local anesthesia, and then midazolam, propofol intravenous; control group only throat local anesthesia, the two groups were observed to feel the degree of discomfort, the reaction in the examination and check before, during and after the blood pressure, Heart rate and oxygen saturation changes, sedation group patients awake time. Results: The degree of discomfort in the sedation group was significantly lower than that in the control group (P <0. 01). The incidences of salivation, nausea and vomiting, restlessness were 4%, 2% and 2% (42%, 24% and 28%, respectively, P <0.01), systolic blood pressure and diastolic blood pressure in the sedation group decreased by 22% and 20% respectively compared with that before the sedation, while the sedation time in the sedation group (1.6 ± 1.4) min. The systolic and diastolic blood pressure in the control group increased by 19% and 17%, respectively, and the heart rate increased by 19% (P <0.01). There was no significant difference in blood pressure, heart rate and oxygen saturation between the two groups before and after the examination. Conclusion: Gastroscopy in patients with hypertension using small doses of midazolam and propofol after intravenous injection can make the whole process without painful response, and good safety