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近十余年来,内分泌学的基础和临床研究有了长足进步。新的概念不断提出,新的激素相继发现,对内分泌疾病发病原理的认识亦逐步深入,致使诊断和治疗方法得到不断完善。本文对近年来国外内分泌学的若干进展作一概述。一、自身免疫性甲状腺疾病自身免疫性甲状腺疾病包括弥漫性毒性甲状腺肿(Graves′病)和慢性淋巴细胞性甲状腺炎(Hashimot′s病)。近年来有证据表明,HLA—DR抗原阳性的甲状腺滤泡上皮细胞在免疫反应中可能充当了抗原提呈细胞(Antigen PresentingCell, APC)的角色,将外来抗原和本身细胞膜
In the past ten years, the basic and clinical research of endocrinology has made great strides. New concepts continue to be proposed, new hormones have been found, the understanding of the pathogenesis of endocrine disease has gradually deepened, resulting in the diagnosis and treatment has been continuously improved. This article summarizes some progress of foreign endocrinology in recent years. First, autoimmune thyroid disease Autoimmune thyroid disease, including diffuse toxic goiter (Graves’ disease) and chronic lymphocytic thyroiditis (Hashimot’s disease). In recent years, there is evidence that HLA-DR antigen positive thyroid follicular epithelial cells may play an antigen presenting cell (Antigen Presenting Cell, APC) role in the immune response, the foreign antigen and its own cell membrane