由过度的Th2反应引起的变态反应性疾病广泛分布在世界各地。众多的炎症细胞与疾病发病机制的多个方面相关,越来越多的证据表明嗜酸粒细胞(eosinophil,EOS)在组织中的局部化和激活可能是疾病发病机制的一个重要因素〔1-2〕。EOS通过释放颗粒蛋白来发挥作用,EOS颗粒蛋白的水平通 Allergic diseases caused by excessive Th2 responses are widely distributed throughout the world. Numerous inflammatory cells are involved in many aspects of the pathogenesis of the disease. There is increasing evidence that the localization and activation of eosinophils (EOS) in tissues may be an important factor in the pathogenesis of the disease [1- 2〕. EOS works by releasing the granule protein, the level of the EOS granule protein passes