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目的探讨血清神经元特异性烯醇化酶（ＮＳＥ）和头颅ＣＴ在新生儿缺氧缺血性脑病（ＨＩＥ）诊断中的作用。方法ＨＩＲ患儿２０例，用酶联免疫法测定生后８天、７天血清ＮＳＥ浓度。生后１周内行头颅ＣＴ检查。结果ＨＩＥ患儿血清ＮＳＥ在生后３天均升高，尤以中、重度明显，与临床分度一致。重度ＨＩＥ患儿头颅ＣＴ分度与临床一致，轻、中度头颅ＣＴ分度与临床不平行。结论血清ＮＳＥ测定是早期诊断ＨＩＥ及判断脑损伤的有效指标，头颅ＣＴ检查结合血清ＮＳＥ测定可更为准确地帮助ＨＩＥ的诊断和治疗。
Objective To investigate the role of serum neuron specific enolase (NSE) and cranial CT in the diagnosis of neonatal hypoxic-ischemic encephalopathy (HIE). Methods Twenty children with HIR were enrolled in this study. Serum NSE concentrations at 8 days and 7 days after birth were measured by enzyme-linked immunosorbent assay. 1 week after birth head CT examination. Results Serum NSE in HIE children increased 3 days after birth, especially in moderate and severe, consistent with the clinical sub-degree. The head of patients with severe HIE CT index consistent with the clinical, mild and moderate head CT indexing and clinical non-parallel. Conclusion Serum NSE is an effective indicator for the early diagnosis of HIE and brain damage. The combination of skull CT and serum NSE can be used to diagnose and treat HIE more accurately.