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目的:初步观察辛苍鼻舒胶囊抗炎作用的有效部位。方法:采用蛋清致小鼠足跖肿胀、醋酸致小鼠腹腔毛细血管炎症、棉球肉芽肿实验,观察辛苍鼻舒胶囊的水提物、挥发油、醇提物的抗炎作用。结果:辛苍鼻舒胶囊中的挥发油、水提物、醇提物分别对蛋清所致小鼠足跖肿胀具有消肿作用,对醋酸致小鼠腹腔毛细血管炎症的急性炎症模型有显著抑制作用,且为醇提物>挥发油>水提物;对棉球肉芽肿均有抑制作用,且醇提物>水提物>挥发油。结论:辛苍鼻舒胶囊醇提物为抗炎最有效部位。
Objective: To observe the effective site of anti-inflammatory effect of Xincang Nishu capsule. Methods: Egg white was used to induce paw edema in mice, intraperitoneal capillary inflammation in mice induced by acetic acid and granuloma of cotton balls were observed. The anti - inflammatory effects of water extract, volatile oil and alcohol extracts of Xincangbizhu capsule were observed. Results: The volatile oil, water extract and alcohol extract in Xincangbizhu capsule had swelling effect on eggplant-induced paw edema and inhibited the acute inflammatory model induced by acetic acid in mice intraperitoneal capillary. , And the alcohol extract> volatile oil> water extract; inhibition of cotton ball granuloma, and alcohol extract> water extract> volatile oil. Conclusion: Xincang nose Shu capsule alcohol extract is the most effective anti-inflammatory sites.