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通过测定尿中NAG酶的活性变化,可早期发现由于肾脏疾病或肾毒性导致的肾小管功能障碍,且检测中假阳性率极低;在疾病活动和毒物持续性存在时,该酶的活性居高不下,而在疾病消除或毒物清除以后则降至正常水平。结合其它肾功能检查不仅可用于疾病的诊断和判断预后,而且由于应用试纸法和简单的药盒即可测定该酶的同功酶,使其具有广泛的应用前景。
By measuring the activity of NAGase in urine, early detection of renal tubular dysfunction caused by kidney disease or nephrotoxicity is extremely low, and the activity of this enzyme is very low in the presence of disease activity and persistence of toxicants High, but after the elimination of the disease or poison clearance was reduced to normal levels. Combined with other renal function tests can not only be used for the diagnosis of disease and prognosis, but also because of the application of the strip method and a simple kit to determine the enzyme isozyme, so that it has a wide range of applications.