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采用４只成年恒河猴，将７５颗健康牙随机分成３组开放根管６个月后经Ｘ光片检查形成根尖周炎，而后经根管预备、封药消毒后行根充，其中Ａ组用氧化锌丁香油糊剂＋吲哚拉新根充；Ｂ组用氧化锌丁香油糊剂根充；Ｃ组空白对照．结果：根充１个半月Ａ，Ｂ两组Ｘ光片根尖周暗影仍明显可见；组织学示Ａ组根尖周炎症基本得以控制，Ｂ组炎症仍明显．３个半月Ｘ光片示Ａ，Ｂ两组尖周暗影明显缩小，无显著性差异，（Ｐ＞００５）；Ａ组根尖周难见到炎性细胞，根尖病变区胶原纤维新生明显，根尖及牙槽骨表面见较多新骨沉积，Ｂ组根尖周仍可见炎细胞浸润，组织新生明显较Ａ组少（Ｐ＜００１）．结果表明：吲哚拉新根管充填能明显抑制根尖周炎症，促进根尖周病变及早修复
Using four adult rhesus monkeys, 75 healthy teeth were randomly divided into three groups of open root canal 6 months after the formation of periapical periodontitis by X-ray examination, and then prepared by root canal, seal disinfection after root filling, which A group with zinc oxide clove oil paste + Indolazine root filling; B group with zinc oxide clove oil paste rooting; C group blank control. Results: 1 and a half months after root filling, radiographs of A and B radiographs were still visible. Histology showed that periapical inflammation of group A was basically controlled and inflammation of group B was still obvious. Three and a half months X-ray showed A and B, the sharpness of the two groups was significantly reduced, no significant difference (P> 005); A group of apical week to see inflammatory cells, apical fibrosis fibrosis Obviously, the apical and alveolar bone surface see more new bone deposition, pericyte group B still inflammatory cell infiltration, tissue regeneration was significantly less than the A group (P <0 01). The results showed that indolla new root canal filling can significantly inhibit periapical inflammation, promote early periapical lesions and early repair