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目的:观察并分析用尼可地尔治疗心绞痛的临床疗效。方法:对2010年12月～2011年12月期间在我院心内科进行诊治的184例心绞痛患者的临床资料进行回顾性研究。我们将这184例患者随机分为对照组和治疗组,每组各有92人。其中,对照组患者使用常规抗心绞痛药物进行治疗,治疗组患者在使用常规抗心绞痛药物进行治疗(所用的药物及药物的用法与对照组患者相同)的基础上,加用尼可地尔进行治疗。30天后,比较两组患者治疗的效果,同时对两组患者在治疗过程中出现不良反应的几率进行比较。结果:治疗组患者治疗的有效率为82.61%,对照组患者治疗的有效率为51.09%。治疗组患者治疗的有效率明显高于对照组患者,二者相比差异具有显著性(p<0.05)。在治疗的过程中,治疗组患者中有4例患者出现了头痛的不良反应,对照组患者中有3例患者出现了头痛的不良反应。两组患者发生不良反应的几率不具有可比性(p>0.05)。结论:用尼可地尔治疗心绞痛疗效确切,可有效地改善患者的临床症状,且引起不良反应的几率较低,值得在临床上推广使用。
Objective: To observe and analyze the clinical efficacy of nicorandil in the treatment of angina pectoris. Methods: The clinical data of 184 patients with angina pectoris diagnosed and treated in our department from December 2010 to December 2011 were analyzed retrospectively. We randomly assigned 184 patients to control and treatment groups, 92 in each group. Among them, patients in the control group were treated with conventional anti-anginal drugs. Patients in the treatment group were treated with nicorandil on the basis of conventional anti-anginal drugs (the same drugs and drugs used were used in the control group) . After 30 days, the effects of treatment in both groups were compared, and the odds of adverse events in the two groups were compared. Results: The effective rate of the treatment group was 82.61%, while that of the control group was 51.09%. The effective rate of the treatment group was significantly higher than that of the control group, the difference was significant (p <0.05). During the course of treatment, 4 patients in the treatment group developed headache and 3 patients in the control group had headache and adverse reactions. The incidence of adverse reactions in both groups was not comparable (p> 0.05). Conclusion: Nicorandil is effective in treating angina pectoris, which can effectively improve the clinical symptoms of patients and has a low risk of adverse reactions. It is worth to be used clinically.