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本文比较了几种螯合利（８１０２、７６０１、８１１、７６０３、８３０７、ＤＴＰＡ）对大鼠急性铀中毒的治疗效果。结果表明．肌肉注射５００ｍｇ／ｋｇ螯合剂．除ＤＴＰＡ外均有明显的促排铀效果，表现为尿铀排出量增加，肾铀蓄积量降低．其中以８１０２效果最好；８１０２不同时间给药（中毒前１ｈ至中毒后４８ｈ），观察到中毒前１ｈ，中毒后立即及中毒后１ｈ给药均有明显的促排铀效果；８１０２对铀所致肾脏损伤的病理改善，以中毒前１ｈ给药组最佳。此时仅见肾曲管上皮细胞轻度水样变性。
This article compared the chelation of several (8102,7601,811,7603,8307, DTPA) acute uranium poisoning in rats. The results show. Intramuscular 500mg / kg chelator. In addition to DTPA have significant effects of promoting uranium, uranium showed increased urinary output, reduced renal uranium accumulation. Among them, 8102 had the best effect; 8102 administered at different times (1h before poisoning to 48h after poisoning), 1h before poisoning, 1h after poisoning and 1h after poisoning were observed. Uranium The pathological improvement of renal injury, poisoning 1h before administration group best. At this point only to see the renal tubular epithelial cells mild watery degeneration.