核磷蛋白(nucleophosmin,NPM)是一个具有多种功能的重要蛋白,定位于核仁,可在胞核与胞浆之间快速穿梭。NPM基因在多种人类肿瘤中过表达,因此被公认为肿瘤标志物和癌基因。后来研究发现NPM也具有抑制肿瘤的功能,它的缺失、突变甚至重排与多种肿瘤的发生密切相关。这表明NPM的作用及其机制非常复杂,可能通过多种机制调控肿瘤的发生。 Nucleophosmin (NPM) is an important protein with multiple functions. It locates in the nucleolus and can rapidly shuttle between nucleus and cytoplasm. NPM gene is overexpressed in a variety of human tumors and is therefore recognized as a tumor marker and oncogene. Later study found that NPM also has tumor suppressor function, its deletion, mutation and even rearrangement are closely related to the occurrence of many kinds of tumors. This shows that the role of NPM and its mechanism is very complex, it may regulate the occurrence of tumors through a variety of mechanisms.