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硅胶(polydimethylsiloxane)作为赋形药已实际应用于甾体激素的长期皮下给药途径,在女性避孕方面很有发展前途。开始试验时只有硅胶囊一种剂型,其后有不同释放率的固体棒与包裹棒等不同新剂型。本研究目的是测定植入 Norplant 胶囊(含左旋18-甲基炔诺酮的皮下胶囊)妇女的血浆左旋18-甲基炔诺酮(以下简称左旋18甲)浓度,并与植入其他不同剂型的血浆左旋18甲浓度作比较。近6年来,使用的植入剂型有5种:6个 Nor-plont 胶囊,3根与6根药棒,4根与6根包裹棒。每一胶囊长34mm,外径2.4mm,内径1.57mm,含左旋18甲结晶约34mg。包裹棒长34mm,直径2.44mm,用薄硅胶包裹,每棒含左旋18甲约50mg。不论何种剂型,植入的方法统一用局麻,以10号套
As an excipient, polydimethylsiloxane has been used as a long-term subcutaneous route of administration of steroid hormones and has great promise in female contraception. At the beginning of the experiment, only one type of silicone capsule was used, followed by different new dosage forms of solid rods and wrapping rods with different release rates. The aim of this study was to determine the plasma concentrations of levonorgestrel 18-norgestone (18-norminal 18-a) in Norplant capsules (subcutaneous capsules containing levonorgestrel 18-norgestrel) Of plasma levonorubicin 18 concentrations for comparison. In the last 6 years, there are 5 implantable dosage forms: six Nor-plont capsules, three and six sticks, four and six wrap sticks. Each capsule is 34 mm long, 2.4 mm in outer diameter, 1.57 mm in inner diameter and contains about 34 mg of L-18 A crystals. Wrap the stick length 34mm, diameter 2.44mm, wrapped with thin silicone, each stick contains about 50mg L-18. Regardless of the dosage form, the method of implantation unified with local anesthesia, to No. 10 sets