论文部分内容阅读
在免疫和炎症反应中细胞因子调节着细胞的生长、分化和功能。细胞因子包括花生四烯酸代谢产物、活性氧(ROS)、多肽激素和肿瘤坏死因子(TNF)等。他们是细胞与细胞交通网络介质。TNF首先 由经内毒素处理过的动物血清中发现,主要由单核/巨噬细胞产生,能引起接纳动物的肿瘤出血、坏死和溶解,故称肿瘤坏死因子。TNF分为两种类型:TNF_α和TNF_β,TNF_β具有淋巴细胞毒作用,故称为淋巴毒素。本文就TNF_β的分子生物学特性与肾脏及其疾病的关系综述如下。
Cytokines regulate the growth, differentiation and function of cells in immune and inflammatory responses. Cytokines include arachidonic acid metabolites, reactive oxygen species (ROS), polypeptide hormones and tumor necrosis factor (TNF) and the like. They are the medium of cell and cell traffic network. TNF was first found in endotoxin-treated animal sera, mainly produced by monocytes / macrophages, which can cause tumor hemorrhage, necrosis and lysis in animals receiving it and is therefore called tumor necrosis factor. TNF is divided into two types: TNF_α and TNF_β, TNF_β with lymphocytotoxicity, it is called lymphotoxin. In this paper, the molecular biology of TNF_β and its relationship with the kidney are summarized below.