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目的:观察中药调味八正散对大鼠慢性细菌性前列腺炎的疗效并探讨作用机理。方法:本实验研究调味八正散对慢性细菌性前列腺炎的影响,使用SD雄性大鼠60只,体重300±20克(由贵阳医学院提供),先将50只大鼠编号,采用编号随机抽取10只作为正常对照组(A),其余40只作为模型组,随机分为4组,每组10只,高、中、低剂量中药汤药灌服组(B、C、D),氧氟沙星对照组(E)。观测指标:(1)大鼠前列腺分泌型免疫球蛋白(SIgA)和白介素8(IL-8)水平;(2)白细胞数和卵磷脂小体密度.结果:调味八正散能显著提高前列腺组织SIgA含量,降低白细胞数,增加卵磷脂小体。对大鼠前列腺白介素8(IL-8)无明显影响;其中高剂量组效果最明显。结论:调味八正散方对大鼠II型前列腺炎有较好的治疗效果。
Objective: To observe the curative effect of traditional Chinese medicine seasoning Bazhengsan on chronic bacterial prostatitis in rats and to explore the mechanism of action. Methods: The experiment was conducted to study the effect of seasoning Bazhengsan on chronic bacterial prostatitis. 60 male SD rats weighing 300±20g (provided by Guiyang Medical College) were used to number 50 rats and randomly numbered. Ten rats were selected as normal control group (A), and the remaining 40 were used as model groups. They were randomly divided into 4 groups with 10 rats in each group. High-, medium-, and low-dose Chinese herbal decoction groups (B, C, D) were used. Astragalus control group (E). Observed indicators: (1) Prostate secretory immunoglobulin (SIgA) and interleukin-8 (IL-8) levels; (2) White blood cell count and lecithin body density. Results: Seasoning Bazheng Powder can significantly increase prostate tissue SIgA content reduces leukocyte counts and increases lecithin bodies. There was no significant effect on rat interleukin-8 (IL-8); the effect was most obvious in the high-dose group. Conclusion: Seasoned Bazhensan Formula has better therapeutic effect on type II prostatitis in rats.