论文部分内容阅读
紫杉醇,是从太平洋紫杉树皮中提取的一种天然双萜。它通过促进微管聚合及抑制其解聚作用,破坏肿瘤细胞增殖和转移所必需的细胞骨架、由于其作用机制及耐药性与破坏DNA的药物如环磷酸胺不同,紫杉醇在治疗耐铂肿瘤(如卵巢癌和乳腺癌)方面成为临床上重要的选用药物。因此,作
Paclitaxel, a natural diterpene extracted from Pacific yew bark. It is through the promotion of microtubule polymerization and inhibition of depolymerization, destruction of tumor cell proliferation and metastasis of the necessary cytoskeleton, because of its mechanism of action and drug resistance and DNA damage drugs such as cyclophosphamide, paclitaxel in the treatment of platinum-resistant tumors (Such as ovarian cancer and breast cancer) become clinically important selection of drugs. So, make