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各种肿瘤异■生成促皮质素(ACTH)而致的柯兴综合征约占 ACTH 依赖性柯兴综合征的20%。作者首次研究蛙皮素(bombesin)对下丘脑-垂体-肾上腺轴的影响,报告1例蛙皮素致垂体 ACTH 依赖性柯兴综合征。病者男性,41岁.面颈部及双手肿胀9个月,4个月内体重增加10kg,且伴肌无力、不适、呼吸短促加重数周入院.患者有典型的柯兴病表现。甲状腺正常,无甲状腺肿及颈淋巴结病。生化检查发现血浆皮质醇显著升高为771～1,550nmol/L,无昼夜节律,小剂量
Various tumors of different coccygeal (ACTH) induced Cushing syndrome accounts for about 20% of ACTH-dependent Cushing’s syndrome. The authors first studied the effects of bombesin on the hypothalamic-pituitary-adrenal axis, and reported one case of clonidine-induced pituitary ACTH-dependent Cushing’s syndrome. Male patient, age 41. Face and neck and hands swollen for 9 months, 4 months weight gain 10kg, and with weakness, discomfort, shortness of breath increased hospitalization for several weeks. Patients with a typical performance of Cushing’s disease. Normal thyroid, no goiter and cervical lymphadenopathy. Biochemical tests found that plasma cortisol was significantly increased to 771 ~ 1,550nmol / L, no circadian rhythm, small doses