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Colestipol(降胆宁)是四乙烯五胺和环表氯醇的共聚体物,是一种人工合成阴离子胆汁酸结合树脂,它在肠道羁留胆汁酸而减少其再吸收。虽然这促进肝内固醇的合成,如肝内胆固醇合成的增加不足以代偿胆固醇的加速分解成胆汁酸,肝内胆固醇储存即降低,导致血浆胆固醇含量减少。因家族性Ⅱ型高脂蛋白血症至少部份是由于富含胆固醇的低密度脂蛋白的分解代谢降低,所以排除胆固醇的药物应该是饮食疗法的一种合理辅助治疗。选择30例动脉粥样硬化患者,男18例,女12例,年龄38～65岁。Ⅱ型高脂蛋白血症的诊断指标是:(1)血清总胆固醇>260毫克％,低密度脂蛋白胆固醇(LDL-C)≥190毫克％;甘油三酯<180
Colestipol is an interpolymer of tetraethylenepentamine and epichlorohydrin, an artificially synthesized anionic bile acid-binding resin that retains bile acids in the intestine to reduce its reabsorption. Although this promotes the synthesis of hepatic sterols, such as increased cholesterol synthesis in the liver is not sufficient to compensate for accelerated decomposition of cholesterol into bile acids, resulting in reduced intrahepatic cholesterol storage resulting in reduced plasma cholesterol levels. Because familial type II hyperlipoproteinemia is at least in part due to the reduced catabolism of cholesterol-rich low-density lipoprotein cholesterol-eliminating drugs should be a reasonable adjunct to dietary therapy. Thirty patients with atherosclerosis were selected, 18 males and 12 females, aged 38-65 years. The diagnostic criteria for type II hyperlipoproteinemia are: (1) serum total cholesterol> 260 mg%, low density lipoprotein cholesterol (LDL-C)> 190 mg%; triglycerides <180