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目的研究中期因子(midkine,MK)在胃癌组织中的表达情况,并探讨其临床意义。方法采用免疫组织化学方法检测我院64例胃癌组织、41例癌前病变、20例正常胃粘膜组织中MK表达情况。结果MK在胃癌组织和高级别上皮内肿瘤及低级别上皮内肿瘤中均有表达,阳性表达率分别为76.6%、17.4%、6.0%,均高于正常组织。MK的表达水平与胃癌的浸润深度、淋巴结转移及临床分期成正相关关系。结论MK在胃癌的生长、侵袭与转移中起重要作用,MK的表达可作为早期诊断及判断胃癌预后的指标。
Objective To study the expression of midkine (MK) in gastric carcinoma and its clinical significance. Methods Immunohistochemistry was used to detect the expression of MK in 64 gastric cancer tissues, 41 precancerous lesions and 20 normal gastric mucosa. Results MK was expressed in gastric cancer, high grade intraepithelial neoplasms and low grade intraepithelial neoplasms. The positive rates of MK were 76.6%, 17.4% and 6.0% respectively, which were higher than those in normal tissues. The expression of MK was positively correlated with the depth of invasion, lymph node metastasis and clinical stage in gastric cancer. Conclusion MK plays an important role in the growth, invasion and metastasis of gastric cancer. The expression of MK can be used as an indicator of early diagnosis and prognosis of gastric cancer.