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目的探讨自身免疫性甲状腺炎(AIT)在多囊卵巢综合征(PCOS)与非PCOS排卵障碍患者中的发生情况。方法收集2012年1月至2013年12月在绍兴市妇幼保健院就诊的排卵障碍者,其中PCOS196例,非PCOS排卵障碍152例,同期因男方因素就诊而卵巢排卵正常者104例为对照组。比较各组甲状腺功能、甲状腺抗体与甲状腺超声检查结果。结果 PCOS组、非PCOS排卵障碍组、正常对照组中AIT的发生率分别为19.9%、7.9%及6.7%,PCOS组与其他两组间比较差异均有统计学意义(P<0.05);非PCOS排卵障碍组与正常对照组间差异无统计学意义(P>0.05)。PCOS组促甲状腺素(TSH)、抗甲状腺过氧化物酶抗体(TPOAb)、抗甲状腺球蛋白抗体(Tg Ab)均显著高于其余两组(P<0.05)。各组间超声阳性结果差异无统计学意义(P>0.05)。结论 AIT在PCOS患者中的发生率高于非PCOS排卵障碍者及正常者;PCOS可能是一种与AIT相关的自身免疫性疾病。
Objective To investigate the occurrence of autoimmune thyroiditis (AIT) in patients with polycystic ovary syndrome (PCOS) and non-PCOS ovulation disorder. Methods One hundred and sixty-five women with ovulation disorder who were treated in Shaoxing Maternal and Child Health Hospital from January 2012 to December 2013 were enrolled. Among them, 196 cases were PCOS and 152 cases were non-PCOS. Ovulation was normal in 104 cases. Thyroid function, thyroid antibodies and thyroid ultrasound examination results were compared between groups. Results The incidence of AIT in PCOS group, non-PCOS ovulation disorder group and normal control group were 19.9%, 7.9% and 6.7%, respectively. There was significant difference between PCOS group and other two groups (P <0.05) PCOS ovulation disorder group and the normal control group no significant difference (P> 0.05). TSH, TPOAb and Tg Ab in PCOS group were significantly higher than those in the other two groups (P <0.05). There was no significant difference in ultrasound positive results among the groups (P> 0.05). Conclusions The incidence of AIT in patients with PCOS is higher than those in non-PCOS patients with ovulation and normal. PCOS may be an autoimmune disease associated with AIT.