【摘 要】
：
Emotional contagion,a primary form of empathy,is present in rodents.Among emotional contagion behaviors,social transmission of fear is the most studied.Here,we modified a paradigm used in previous studies to more robustly assess the social transmission of
【机 构】
：
Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain
论文部分内容阅读
Emotional contagion,a primary form of empathy,is present in rodents.Among emotional contagion behaviors,social transmission of fear is the most studied.Here,we modified a paradigm used in previous studies to more robustly assess the social transmission of fear in rats that experienced foot-shock.We used resting-state functional magnetic resonance imaging to show that foot-shock experience enhances the regional connectivity of the anterior cingulate cortex (ACC).We found that lesioning the ACC specifically attenuated the vicarious freezing behavior of foot-shock-experienced observer rats.Furthermore,ablation of projections from the ACC to the mediodorsal thalamus (MDL) bilaterally delayed the vicarious freezing responses,and activation of these projections decreased the vicarious freezing responses.Overall,our results demonstrate that,in rats,the ACC modulates vicarious freezing behavior via a projection to the MDL and provide clues to understanding the mechanisms underlying empathic behavior in humans.
其他文献
Neuroscience is the scientific study of how the nervous system develops,its structure,and what it does.With the development of different sciences and technologies,neuroscience has become an interdisciplinary science that collaborates with other fields,and
Spinal cord injury(SCI)is an ever-increasing challenge.Severe injury can cause long-term loss of sensory and motor functions,as well as other chronic conditions,such as neuropathic pain and autonomic dysreflexia.So far,most research has been focused on ac
Chronic pain is a major health problem world-wide,According to a recent report in the New England Journal of Medicine [1],the prevalence of pain in the United States is striking:more than 116 million Americans have pain that persist for weeks to years.Chr
Efficient viral vectors for mapping and manipulating long-projection neuronal circuits are crucial in structural and functional studies of the brain.The SAD strain rabies virus with the glycoprotein gene deleted pseudotyped with the N2C glycoprotein (SAD-
Multiple sclerosis (MS) is a chronic and incurable autoimmune neurodegenerative disease of the central nervous system.Although the symptoms of MS can be managed by vitamin D3 treatment alone,this condition cannot be completely eradicated.Thus,there might