有证据表明,处于发育过程中的卵泡是白细胞介素(IL)的作用位点,卵巢细胞能够分泌IL,而且这些细胞同时做为IL调节的靶位点存在。在许多哺乳动物都发现IL家族分布在不同的卵巢细胞(卵母细胞、颗粒细胞、卵泡膜细胞)当中。排卵时IL-1在人和猪的卵泡液中具有相似的生物学活性。尽管有证据证明IL-1参与了排卵过程和卵母细胞的成熟过程,但其在卵巢中的作用机制尚不十分清楚。IL-1可能参与了排卵的某些相关过程,如蛋白酶的合成、血纤维蛋白溶酶原激活剂活性的调节、前列腺素和一氧化氮的合成。IL-1还调节卵巢甾体激素合成。 Evidence suggests that follicles in development are the site of action of interleukin (IL), which secretes IL, and these cells also act as target sites for IL regulation. In many mammals, the IL family is found in different ovarian cells (oocytes, granulocytes, orca cells). IL-1 has similar biological activity in human and porcine follicles during ovulation. Although there is evidence that IL-1 involved in the process of ovulation and oocyte maturation, but its role in the ovary mechanism is not yet clear. IL-1 may be involved in some of the ovulation related processes, such as protease synthesis, plasminogen activator activity regulation, prostaglandin and nitric oxide synthesis. IL-1 also regulates ovarian steroid hormone synthesis.