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目的：观察外周应用４－ＭＣ对老龄鼠学习、记忆功能的影响，以期对４－ＭＣ能否促进中枢神经系统内源性ＮＧＦ的产生，并进而通过ＮＧＦ改善老龄鼠的脑功能做进一步的研究．方法：１０ｇ／ｋｇ体重小鼠腹腔内注射给药，对照组１０ ｍｍｏｌ／Ｌ的维生素 Ｃ溶液等量，用药１周后行Ｍｏｒｒｉｓ水迷宫训练，连续７ｄ，第１５天进行一次水迷宫测试，记录其逃生时间．考查空间定位的学习和记忆能力．结果：实验结果证实了外周应用４－ＭＣ小鼠空间定位的学习记忆能力明显优于对照组（Ｐ＜０．０５）．提示：４－ＭＣ是一种有前途的，值得深。研究的有促智潜能的药物．
OBJECTIVE: To observe the effects of peripheral 4-MC on learning and memory function in aged rats in order to further investigate whether 4-MC can promote the production of endogenous NGF in the central nervous system and further improve the brain function of aged rats by NGF . Methods: The mice in 10g / kg body weight were injected intraperitoneally with the same volume of vitamin C solution of 10 mmol / L in the control group. Morris water maze training was performed for 1 week. After 7 days, the water maze test was performed on the 15th day. time. Examining spatial learning and memory skills. Results: The experimental results confirmed that peripheral learning and memory ability of 4-MC mice was significantly better than that of the control group (P <0.05). Tip: 4-MC is a promising, worth deep. There are potent drugs studied.