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目的观察血管内皮生长因子(vascular endothelial growth factor,VEGF)及雌激素受体(estrogen receptor,ER)、孕激受体(progestogen receptor,PR)、雄激素受体(androgen receptor,AR)在颈鼓室副神经节瘤的表达,分析其与肿瘤生物学行为的关系。方法回顾性分析17例颈鼓室副神经节瘤的临床资料,对其存档的手术标本行Envision法免疫组织化学检查,并运用SPSS 10.0 for Windows对资料进行Spearman等级相关分析。结果在17例标本中,11例表达VEGF,且表达强度与Fisch分级相关,r=0.529,P<0.05;无1例表达ER、PR及AR。结论 VEGF可能对颈鼓室副神经节瘤的生长有促进作用;颈鼓室副神经节瘤的性别偏向似乎与性激素异常无关。
Objective To observe the expression of vascular endothelial growth factor (VEGF), estrogen receptor (ER), progestogen receptor (PR) and androgen receptor (AR) Paraganglioma expression, analysis of its relationship with the biological behavior of the tumor. Methods The clinical data of 17 cases of paraganghual ganglioma were retrospectively analyzed. Envision immunohistochemistry was performed on the archived surgical specimens. Spearman rank correlation analysis was performed using SPSS 10.0 for Windows. Results Among the 17 specimens, 11 cases expressed VEGF, and the expression intensity correlated with Fisch grade (r = 0.529, P <0.05). No cases expressed ER, PR and AR. Conclusion VEGF may promote the growth of paraganglioma of the neck and tympanic cavity. The gender preference of paraganglioma of the neck and tympanum seems to be unrelated to the abnormality of sex hormones.