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为探讨新生儿细胞色素P4 5 0 2E1(CYP2E1)基因多态性和对氧磷酶 2 (二乙基对硝基苯磷酸酯酶 2 )基因(PON2 ) 14 8位点多态性对早产的影响 ,采用横断面调查方法 ,使用统一的调查表 ,由安庆市各县医院对入院分娩孕妇及其单胎、活产、早产和对照新生儿进行调查 ,共得到有效样本 2 0 9个母亲 新生儿对。单因素分析结果显示 :CYP2E1野生纯合子基因型 ( + + )与突变纯合子基因型 ( - - ) 杂合子基因型 ( + - )比较 ,对早产的影响不具有统计学意义。而PON2Ala14 8Ala纯合子基因型与Gly14 8Gly纯合子基因型 Ala14 8Gly杂合子基因型比较 ,对早产的影响具有显著的统计学意义。进一步分析CYP2E1基因 5′端RsaⅠ位点多态性和PON2基因 14 8位点多态性是否存在交互作用 ,结果显示 :CYP2E1野生纯合子基因型和PON2Ala14 8Ala纯合子基因型这一组合与参照组比较 ,对早产的影响有显著的统计学意义。基因CYP2E15′端RsaⅠ位点多态性与新生儿早产不相关 ,但基因PON2 14 8位点多态性与新生儿早产相关 ,且CYP2E15′端RsaⅠ位点多态性和PON2 14 8位点多态性之间对早产的影响存在交互作用
To investigate the relationship between neonatal cytochrome P450 2E1 (CYP2E1) polymorphism and polymorphism of paraoxonase 2 (PON2) 14 8 polymorphism in preterm labor The cross-sectional survey method was used to investigate the pregnant women and their singletons, live births, premature births and control newborns admitted to hospitals in Anqing by using a unified questionnaire. A total of 209 new valid samples were obtained from mothers Right. The results of univariate analysis showed that there was no significant difference between the genotypes of + + and + CYP2E1 homozygous genotypes (+ -) in homozygous mutant homozygous genotypes (-). The PON2Ala14 8Ala homozygous genotype and Gly148Gly homozygous genotype Ala148Gly heterozygous genotypes, the impact on preterm birth was statistically significant. Further analysis of CYP2E1 gene 5 ’Rsa Ⅰ site polymorphism and PON2 gene 14 8 polymorphism whether there is interaction, the results showed: CYP2E1 wild homozygous genotype and PON2Ala14 8Ala homozygote genotype and the reference group The impact on preterm birth was statistically significant. The polymorphism of the RsaI site of CYP2E15 ’end was not related to neonatal preterm birth, but the gene PON2148 polymorphism was associated with neonatal preterm birth. The RsaI polymorphism of CYP2E15’ end and the polymorphism of PON2148 locus There is an interaction between morphological effects on preterm birth