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目的 :检测正常人及Graves眼病患者 2 4小时尿氨基葡聚糖 (glycosaminoglycan ,GAG)的含量 ,探讨其作为Graves眼病活动性指标的意义。方法 :按照年龄段检测正常人 2 4小时GAG的含量 ,获得正常人 2 4小时尿GAG值 ,同时检测活动期Graves眼病 (GravesOphthalmopathy ,GO)患者的 2 4小时GAG含量 ,对其中参与治疗的 5例GO患者随诊其治疗前后GAG值。结果 :6 0例正常人 2 4小时尿中GAG总量为 (19 70± 9 72 )mg/2 4h。性别、年龄之间GAG值无显著性差异。活动期GO患者 2 3例 ,2 4小时尿中GAG的总量平均为 (35 5± 11 4)mg/2 4h ,与正常人组比较有显著性差异 (P <0 0 5 )。检测 5例GO患者治疗前 /后的尿GAG含量 ,分别为 :97 3/5 0 6 ,5 2 3/18 5 ,33 2 /5 4,31 2 /15 8,31 6 /11 1(mg/2 4h)。结论 :2 4小时尿氨基葡聚糖可作为GO活动度的一项指标
Objective: To detect the content of 24-hour urine glycosaminoglycan (GAG) in normal and Graves ophthalmopathy patients, and to explore its significance as an indicator of activity of Graves ophthalmopathy. Methods: The 24-hour GAG was detected by age group, 24 hours urinary GAG was measured in normal subjects, 24 hours GAG was measured in active Graves ophthalmopathy (GO) patients, and 5 cases were involved in the treatment of 5 Cases of GO patients were followed up before and after treatment GAG value. Results: The total amount of GAG in 24 hours urine of 60 normal people was (19 70 ± 9 72) mg / 24 h. There was no significant difference in GAG between sex and age. In the active GO group, the total amount of GAG in 24 hours was (35 5 ± 11 4) mg / 24 h in 24 cases, which was significantly different from that in the normal group (P 0 05). Urinary GAG levels were measured before and after treatment in 5 GO patients, respectively: 97 3/5 0 6, 5 2 3/18 5, 33 2/5 4, 31 2/15 8, 31 6/11 1 (mg / 2 4h). CONCLUSION: 24-hour urine aminodextran can be used as an indicator of GO activity