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目的研究毛冬青中木质素类化学成分。方法采用硅胶柱色谱法、ODS柱色谱法、Sephedax LH-20柱色谱法、薄层色谱法及高效液相色谱法等方法对毛冬青体积分数70%乙醇提取物进行分离纯化,并根据理化性质及波谱数据鉴定分离得到化合物。结果分离得到10个木脂素类化合物,经鉴定分别为(7R,7′R,7″R,8S,8′S,8″S)-4′,4″-dihydroxy-3,3′,3″,5-tetramethoxy-7,9′:7′,9-diepoxy-4,8″-oxy-8,8′-sesquineolignan-7″,9″-diol(1)、erythro-(7S,8R)-1-(4-hydroxy-3-methoxyphenyl)-2-{4-[(E)-3-hydroxy-1-propenyl]-2-methoxyphe-noxy}-1,3-propanediol(2)、erythro-(7R,8S)-1-(4-hydroxy-3-methoxyphenyl)-2-{4-[(E)-3-hydroxy-1-propenyl]-2-methoxyphe-noxy}-1,3-propanediol(3)、erythro-(7R,8S)-guaiacylglycerol-β-coniferyl aldehyde ether(4)、erythro-(7S,8R)-guaiacylglycerol-β-coniferyl aldehyde ether(5)、Vladinol D(6)、7S,8R-dihydrodehydroconiferyl alcohol(7)、(-)-丁香酯素[(-)-syringaresinol,8]、(-)-杜仲树脂酚[(-)-medioresinol,9]、(+)-环橄榄树脂素[(+)-cyclo-olivil,10]。结论化合物1~7为首次从冬青属植物中分离得到。
Aim To study the chemical composition of lignin in Mao Dongqing. Methods Silica gel column chromatography, ODS column chromatography, Sephedax LH-20 column chromatography, TLC and HPLC methods were used to separate and purify the 70% ethanol extract of Mao dongqing. According to the physicochemical properties And spectral data were isolated and identified compounds. Results Ten lignan compounds were isolated and identified as (7R, 7’R, 7 “R, 8S, 8’S, 8” S) -4 ’, 4 “-dihydroxy-3,3’ 3 ”, 5-tetramethoxy-7,9 ’: 7’, 9-diepoxy-4,8“ -oxy-8,8’-sesquineolignan-7 ”, 9" -diol (1), erythro- ) - 1 - (4-hydroxy-3-methoxyphenyl) -2- {4 - [(E) - (7R, 8S) -1- (4-hydroxy-3-methoxyphenyl) -2- {4- [(E) -3-hydroxy- 1 -propenyl] -2-methoxyphe-noxy} (3) erythro- (7R, 8S) -guaiacylglycerol- [beta] -coniferyl aldehyde ether (4), erythro- (7S, 8R) -guaiacylglycerol- [beta] -coniferyl aldehyde ether (5), Vladinol D (-) - Syringaresinol, 8], (-) - Eucommia resin phenol [(-) - medioresinol, 9] [(+) - cyclo-olivil, 10] .Conclusion Compounds 1 to 7 were isolated from the genus Ilex for the first time.