有关人眼角膜内皮发育的认识包括三个方面:(1)人眼角膜内皮来自神经嵴;(2)人眼角膜内皮发育是相当复杂的;(3)对角膜内皮病理过程的了解与分类,神经嵴非常重要。人眼角膜内皮的神经嵴起源角膜内皮起源于表面外胚层下积聚在视杯围围的细胞群。最初这些细胞群起源于中胚层,称为原始间质。其后移动到原始间质中的神经嵴细胞形成更复杂的异质性细胞群,称为继发间质。许多眼眶和眼球结构来自继发间质细胞。继发间质中两种不同来源的细胞在形态学上很相似,用光学或电子显微镜检查不能加以区分。由于上述原因及对胚胎学神经嵴的认识尚不完全,人们最初认为大多数眼球结构来自继发间质的中胚层成分。1974年,Johnston及其同事把标记的鹌鹁神经嵴细胞植入鸡胚的神经嵴部位证明继发间质对眼球发育所起的作用较前认为的更大些,并指出是继发间质中的神经嵴成分发 There are three aspects about the development of human corneal endothelium: (1) the cornea of ​​human cornea originates from the neural crest; (2) the development of human corneal endothelium is rather complex; (3) the understanding and classification of corneal endothelial pathology, Neural crest is very important. Origin of neural crest of human corneal endothelium The corneal endothelium originates from a population of cells that accumulate in the optic cup under surface ectoderm. These cell populations originally originated in the mesoderm, called the primitive mesenchyme. Neural crest cells that subsequently migrate into the original interstitium form a more complex heterogeneous population of cells called the secondary stroma. Many orbital and ocular structures come from secondary stromal cells. Cells from two different sources in the secondary stroma are morphologically similar and can not be distinguished by optical or electron microscopy. Due to the above reasons and the incomplete understanding of the embryonic neural crest, most of the ocular structures were originally thought to originate from the mesodermal composition of secondary stroma. In 1974, Johnston and colleagues planted the labeled quail neural crest cells into the neural crest of chicken embryos to demonstrate that the secondary stroma contributes more to the development of the eye than previously thought, and states that the secondary stroma In the neural crest hair component