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目的:探讨口服四种维生素[维生素E(Vit E)+叶酸(FA)+维生素B2(Vit B2)+维生素B12(Vit B12)]联合FE复合酶含漱治疗复发性口腔溃疡(ROU)的临床效果及对患者血清炎性因子水平的影响。方法:选取我院2014年1月~2016年2月收治的126例ROU患者,采用随机数字表法均分为两组。对照组予以FE复合酶治疗,观察组在此基础上口服四种维生素(Vit E+FA+Vit B2+Vit B12)治疗。记录比较两组的局部疗效、远期疗效,治疗前后血清炎性因子水平以及不良反应的发生情况。结果:与对照组相比,观察组治疗30d后疼痛指数显著降低(P<0.01),平均溃疡期显著缩短(P<0.01)。治疗后6个月,观察组总有效率为95.2%,较对照组明显上升(81.0%,P<0.05)。与治疗前对比,两组治疗30 d后血清TNF-α、IL-17水平均显著降低(P<0.01),IL-2水平均显著升高(P<0.01);且观察组以上各炎性因子的改善效果均更为显著(P<0.01)。两组不良反应率对比差异无统计学意义(P>0.05)。结论:口服四种维生素联合FE复合酶含漱治疗复发性口腔溃疡更能有效促进溃疡创面愈合,减轻疼痛,调节机体促/抗炎因子平衡,提高远期治疗效果,且安全性高。
Objective: To investigate the clinical efficacy of oral administration of four vitamins (Vit E + FA + Vit B2 + Vit B12) combined with FE complex enzyme in the treatment of recurrent oral ulcer (ROU) Effect and its effect on the levels of serum inflammatory cytokines in patients. Methods: A total of 126 ROU patients admitted from January 2014 to February 2016 in our hospital were randomly divided into two groups. The control group was treated with FE enzyme complex, and the observation group was treated with four vitamins (Vit E + FA + Vit B2 + Vit B12) on the basis of this. The local efficacy, long-term efficacy, serum levels of inflammatory cytokines and the incidence of adverse reactions before and after treatment were recorded and compared between the two groups. Results: Compared with the control group, the pain index of the observation group decreased significantly (P <0.01) and the average ulcer period significantly shortened (P <0.01) 30d after the treatment. At 6 months after treatment, the total effective rate in the observation group was 95.2%, which was significantly higher than that in the control group (81.0%, P <0.05). Compared with those before treatment, the levels of TNF-α and IL-17 in both groups were significantly decreased (P <0.01) and IL-2 levels were significantly increased after 30 days treatment (P <0.01) Factors to improve the effect were more significant (P <0.01). There was no significant difference in adverse reactions between the two groups (P> 0.05). CONCLUSION: Oral administration of four vitamins combined with FE complex enzyme rinse for the treatment of recurrent aphthous ulcer is more effective in promoting ulcer wound healing, relieving pain, regulating the balance of pro-inflammatory and anti-inflammatory factors and improving the long-term therapeutic effect, and is safe.