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目的探讨老年冠心病患者中阿司匹林抵抗的发生率和临床特点。方法选取就诊前至少1月以上未服用阿司匹林等抗血小板聚集药物的确诊老年冠心病患者50例。检测分别由ADP和AA诱导的PAG等各项指标,然后给予阿司匹100mg/d口服治疗,2周后复查上述各项化验指标,前后对照。根据PAG判定AR,将患者分为阿司匹林抵抗组(AR)和阿司匹林敏感组(AS),对比两组差别。结果50例冠心病患者中有6例由ADP和AA诱导的PAG均高于判定标准,AR发生率为12%。结论通过检测PAG发现,服用阿司匹林的老年冠心病患者中有12%存在阿司匹林抵抗现象。
Objective To investigate the incidence and clinical features of aspirin resistance in elderly patients with coronary heart disease. Methods Fifty patients with diagnosed elderly patients with coronary heart disease who did not take aspirin and other antiplatelet drugs at least one month before treatment were selected. The indexes such as PAG induced by ADP and AA were detected respectively, then treated with aspirin 100mg / d orally. After 2 weeks, the above indexes were reviewed and compared before and after. Patients were divided into aspirin resistance group (AR) and aspirin sensitive group (AS) according to the PAG judgment AR, and the differences between the two groups were compared. Results Among the 50 patients with coronary heart disease, 6 cases of PAG induced by ADP and AA were higher than the standard. The incidence of AR was 12%. Conclusions As detected by PAG, aspirin resistance was observed in 12% of elderly patients taking aspirin.