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作者用流式细胞术对５１例大肠癌和８６例乳腺癌患者的癌灶、癌旁组织和淋巴结转移灶细胞进行了ＤＮＡ含量和增殖活性（ＳＰＦ）的对比研究。结果表明，癌旁组织是否出现ＤＮＡ异倍体细胞，与癌灶关系不大。这提示，癌旁异倍体细胞群的出现可能是致癌因子的直接作用。在癌灶、癌旁和淋巴结对比研究时剔除各组的二倍体标本后，其异倍体病例间比较时发现癌灶ＤＩ值与淋巴结的十分接近（大肠癌分别为１．５６和１．５２）；乳腺癌则分别为１．７３和１．７０），癌旁组织则明显减低（分别为１．１９和１．５９）；其ＳＰＦ也显示了类似的变化规律。这表明，癌灶和淋巴结中癌细胞的生物学特性十分相似。这提示，淋巴结中的恶性细胞可能是直接从癌灶转移过来的，而癌旁组织的恶性细胞可能是新生的。
The authors used flow cytometry to compare the DNA content and proliferative activity (SPF) of 51 cases of colorectal cancer and 86 cases of breast cancer with tumor foci, paracancerous tissues, and lymph node metastases. The results showed that whether or not paracancerous tissue cells exhibited DNA heteroploid cells was not associated with cancer foci. This suggests that the appearance of paraneoplastic paraneoplastic cell populations may be a direct effect of carcinogenic factors. When the diploid specimens of each group were excluded from the comparison of cancer foci, paraneoplastic and lymph nodes, the DI value of foci was very close to that of lymph nodes when they were compared between aneuploid cases (colorectal carcinomas were 1.56 and 1. 52); breast cancer were 1.73 and 1.70), respectively, adjacent tissue was significantly reduced (1.19% and 1.59, respectively); its SPF also showed a similar pattern of changes. This shows that the biological characteristics of cancer cells in cancer foci and lymph nodes are very similar. This suggests that the malignant cells in the lymph nodes may be transferred directly from the foci, and the malignant cells in the adjacent tissues may be new.