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常规激素治疗基础上加用静脉环磷酰胺冲击治疗小儿狼疮性肾炎（ＬＮ），环磷酰胺（ＣＴＸ）每２周１次，每次２日，每日８～１２ｍｇ／ｋｇ静脉给药，累积量≤１５０ｍｇ／ｋｇ，逐渐延长至每月、每３个月、每６个月１次的用药方案治疗ＬＮ１５例。观察１年内的疗效。结果：ＣＴＸ治疗后１个月贫血明显改善，补体Ｃ３恢复，血沉下降至正常，２４小时尿蛋白定量减少，３个月后显著减少，血清肌酐及尿素氮在治疗过程中逐渐下降，肾功能不全者获得改善或恢复。该法能够有效地控制ＬＮ活动，血尿和蛋白尿明显减轻，改善肾功能。临床应用时尚须注意副作用及复发问题。
Routine hormone therapy plus intravenous cyclophosphamide shock treatment of children with lupus nephritis (LN), cyclophosphamide (CTX) once every two weeks, each on the 2nd, daily 8 ~ 12mg / kg intravenous administration, accumulation Amount ≤ 150mg / kg, gradually extended to every month, every 3 months, once every 6 months treatment regimen LN15 cases. Observe the effect within 1 year. Results: After 1 month of CTX treatment, anemia was significantly improved, C3 recovery was recovered, erythrocyte sedimentation rate was decreased to normal, 24-hour urinary protein was decreased quantitatively, decreased significantly after 3 months, serum creatinine and urea nitrogen decreased gradually during treatment, renal insufficiency Get improved or recovered. The method can effectively control LN activity, hematuria and proteinuria significantly reduced, improve renal function. Clinical application of fashion should pay attention to the side effects and recurrence problems.