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目的探讨甲泼尼龙及氢化可的松在过敏性紫癜患儿中的临床效果差异。方法选择我院过敏性紫癜患儿共80例,随机分为观察组和对照组。两组均给予常规治疗,观察组给予甲泼尼龙,对照组同时给予氢化可的松。观察两组患儿皮疹、腹痛等症状缓解情况。结果观察组皮疹、腹痛、便血、关节疼痛症状早于对照组缓解,差异有统计学意义(P<0.05)。观察组显效31例,有效7例,无效2例,对照组显效23例,有效8例,无效9例,观察组总有效率和对照组总有效率分别为95.0%和77.5%,观察组总有效率显著高于对照组(P<0.05)。结论甲泼尼龙在治疗过敏性紫癜患儿方面优于氢化可的松,其缓解症状所需时间短,临床治疗效果高于氢化可的松。
Objective To investigate the clinical effects of methylprednisolone and hydrocortisone in children with Henoch-Schonlein purpura. Methods A total of 80 children with allergic purpura in our hospital were randomly divided into observation group and control group. Both groups were given routine treatment, the observation group given methylprednisolone, while the control group given hydrocortisone. Observation of two groups of children with rash, abdominal pain and other symptoms ease. Results The rash, abdominal pain, blood in the stool and joint pain in the observation group were earlier than those in the control group, with significant difference (P <0.05). The observation group was markedly effective in 31 cases, effective in 7 cases, ineffective in 2 cases, the control group markedly effective in 23 cases, effective in 8 cases and ineffective in 9 cases. The total effective rate in the observation group and the control group were 95.0% and 77.5% The effective rate was significantly higher than that of the control group (P <0.05). Conclusion Methylprednisolone is superior to hydrocortisone in the treatment of children with Henoch-Schonlein purpura, and its time to relieve symptoms is short, and the clinical effect is better than that of hydrocortisone.