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Cogan氏综合征是一种多系统性炎症性血管病,其特征为非梅毒性间性角膜炎和迷路-听症状,于1945年首先由Cogan所报告。最近发现Cogan氏综合征可有其它系统的损害,包括呼吸系、心血管、胃肠、骨骼和神经系统损害。一般症状有发热、寒颤和体重减轻;周围血白细胞增多,血沉加快。眼症状可表现为非梅毒性间质性角膜炎,反复发作的角膜溃疡和虹膜睫状体炎,巩膜表面炎,结合膜炎,视网膜血管闭塞等。耳症状可表现为前庭功能障碍、听力减退、耳聋
Cogan’s Syndrome is a multi-systemic inflammatory vascular disease characterized by non-syphilitic keratitis and labyrinthine hearing symptoms, first reported by Cogan in 1945. Cogan’s syndrome has recently been found to have other systemic damage, including respiratory, cardiovascular, gastrointestinal, skeletal and nervous system impairments. The general symptoms of fever, chills and weight loss; peripheral leukocytosis, ESR faster. Eye symptoms can be manifested as non-syphilitic interstitial keratitis, recurrent corneal ulcers and iridocyclitis, scleral surface inflammation, conjunctivitis, retinal vascular occlusion and so on. Ear symptoms can be manifested as vestibular dysfunction, hearing loss, deafness