已知神经管缺损的出生率各地不尽一致,英国最高(6.1/1000),美国黑人最低(1.6/1000)。该病大部分以单纯畸形出现在染色体正常的新生儿中;同时,还可以单基因遗传的综合征的一部分而出现(如Meckel综合征),也可作为染色体不平衡综合征的一部分而出现(如18三体和三倍体)。以前的研究表明,在自发流产儿中的神经管缺损(NTD)发生率比足月新生儿的发生率高10倍,提示在宫内对具有这种缺陷的胚胎的选择性很有效,有人认为NTD The birth rate of neural tube defects is known to vary everywhere, with the highest in the UK (6.1 / 1000) and the lowest in the United States of America (1.6 / 1000). Most of the disease occurs as simple abnormalities in normal-chromosome neonates; it can also occur as part of a monogenic syndrome (such as Meckel’s syndrome) or as part of a chromosomal imbalance syndrome Such as trisomy 18 and triploid). Previous studies have shown that the incidence of neural tube defects (NTD) in spontaneous abortion is 10 times higher than that of full-term newborns, suggesting that intrauterine selectivity of embryos with this defect is very effective, NTD