本文对我科新生儿病房收治的１５０例ＨＩＥ患儿进行了临床观察分析。结果：本组患儿９２例并发多器官损害，发生率６１．３％，其中肾脏损害发生率５２％，其次为肺脏损害３２％。ＨＩＥ分度不同损害器官情况亦不同，轻度无多器官损害，中度多器官损害发生率６３．８％，重度则全部并发多器官损害，明显高于轻中度患儿。多器官损害的病死率与其分度有关，中度病死率３．３％，重度病死率４３％，（Ｐ＜０．０１）有显著性差异。提示：ＨＩＥ严重程度与累及器官损害数、病死率呈正相关。多器官损害的程度、数目与日龄、胎龄、出生体重有关，与５分钟Ａｐｇａｒ评分≤５分及窒息程度密切相关，文中讨论提出防治措施。 In this paper, 150 cases of HIE admitted to neonatal ward of our department were analyzed clinically. Results: 92 cases of this group of children complicated by multiple organ damage, the incidence rate of 61.3%, of which 52% incidence of kidney damage, followed by lung damage 32%. HIE classification of different organ damage are also different, mild without multiple organ damage, moderate multiple organ damage rate of 63.8%, severe all complicated by multiple organ damage was significantly higher than mild to moderate children. The mortality rate of multiple organ damage was related to its degree of division, with a moderate mortality rate of 3.3% and a severe mortality rate of 43% (P <0.01). Hint: The severity of HIE is related to organ damage and mortality. The extent of multiple organ damage, the number and age, gestational age, birth weight, and 5 minutes Apgar score ≤ 5 points and the degree of asphyxia is closely related to the prevention and treatment measures discussed in the article.