胎肝细胞(FLC)悬液富含粒、红系祖细胞,其中造血干细胞(CD34~+)的增殖能力比成年骨髓高3倍,且淋巴细胞含量少,移植物抗宿主(GVHD)反应低下,采用异基因胎肝细胞输注无疑克服了异基因骨髓移植配型不合的并发症.木研究对促进骨髓粒、单系为主的造血前体细胞分化、成熟作用确切的GM-CSF基因通过重组腺病毒转染至小鼠胎肝细胞,脾内移植于大剂量化疗后的同种异基因小鼠体内,观察了这种GM-CSF基因疗法对造血功能恢复的影响. The fetal liver cell (FLC) suspension is rich in granulocytes and erythroid progenitor cells, in which the hematopoietic stem cells (CD34~+) are three times more proliferative than adult bone marrow, and the lymphocyte content is low, and the graft-versus-host (GVHD) response is low. The use of allogeneic fetal liver cell transfusions undoubtedly overcomes the complications associated with mismatched allogeneic bone marrow transplantation. Wood studies have confirmed the role of GM-CSF genes in promoting the differentiation and maturation of hematopoietic progenitor cells, which are mainly composed of bone marrow and monolines. Recombinant adenovirus was transfected into mouse fetal liver cells and transplanted into allogeneic mice after high dose chemotherapy in the spleen. The effect of this GM-CSF gene therapy on hematopoietic recovery was observed.