论文部分内容阅读
类风湿关节炎(rheumatoid arthritis,RA)是一种主要累及周围对称性小关节为主的自身免疫性炎症疾病。近年来发现RA患者心血管疾病发病率明显高于普通人群,并能够缩短RA病人生存年限达5～10年。RA病人大部分心血管疾病均源于血管动脉粥样硬化。对氧磷酶-1是体内一种重要抗氧化剂,RA病人从氧化应激水平升高、造成其基因多态性、炎症反应等多个方面,降低对氧磷酶-1活性水平,从而促进RA患者动脉粥样硬化的形成,在本文中作者就相关内容进行探讨。
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease that mainly affects the symmetrical facet joints. In recent years, found that the incidence of cardiovascular disease in patients with RA was significantly higher than the general population, and can shorten the survival of RA patients for 5 to 10 years. Most patients with RA have cardiovascular disease derived from atherosclerosis. Paraoxonase-1 is an important anti-oxidant in vivo, and RA patients reduce the level of paraoxonase-1 activity from the aspects of oxidative stress, gene polymorphism and inflammatory response, and thus promote The formation of atherosclerosis in RA patients is discussed in this article by the authors.