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经皮冠状动脉介入治疗的应用改善了冠心病患者的临床症状及预后,但现在困扰人们的问题是作为其术后并发症之一的支架内再狭窄发病率仍然很高。大量的研究证实,内膜增生在支架内再狭窄的形成中起主导作用,所以提高受损内膜再内皮化的速度是防止支架内再狭窄的一个重要措施。新近的研究表明,内皮祖细胞能参与损伤后血管内皮修复,促进受损血管内膜的再内皮化,因此,在防止支架内再狭窄中将得到进一步的研究与应用。因此,本文就内皮祖细胞在支架术后再内皮化中应用的研究进展做一综述。
The application of percutaneous coronary intervention improves the clinical symptoms and prognosis of patients with coronary heart disease, but the problem now plaguing people is the high incidence of in-stent restenosis as one of its postoperative complications. A large number of studies have shown that intimal hyperplasia plays a leading role in the formation of in-stent restenosis. Therefore, increasing the rate of re-endothelialization of damaged endothelium is an important measure to prevent in-stent restenosis. Recent studies have shown that endothelial progenitor cells can participate in vascular endothelial repair after injury and promote the re-endothelialization of damaged vascular intima. Therefore, further study and application will be carried out to prevent in-stent restenosis. Therefore, this review summarizes the research progress of endothelial progenitor cells in endothelial reendothelialization.